MovDisordV3, Main, Exploration, bibRecord, 002C98

PET evidence of central GABAergic changes in stiff‐person syndrome

Identifieur interne : 002C98 ( Main/Exploration ); précédent : 002C97; suivant : 002C99

PET evidence of central GABAergic changes in stiff‐person syndrome

Auteurs : Daniela Perani [Italie] ; Valentina Garibotto [Italie] ; Andrea Panzacchi [Italie] ; Rosa Maria Moresco [Italie] ; Paola Ortelli [Italie] ; Massimo Corbo [Italie] ; Ferruccio Fazio [Italie] ; Franco Folli [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-05-15.

RBID : ISTEX:FF5ACEFD92831171FAF99F889FC39B417948023B

Descripteurs français

Pascal (Inist)
- Flumazénil, GABA, Positon, Système nerveux pathologie, Tomographie émission positon, Tomoscintigraphie.

English descriptors

KwdEn :
- 11C‐flumazenil, Emission tomography, Female, Flumazenil, GABA, Humans, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Positron, Positron emission tomography, Positron-Emission Tomography, Stiff-Person Syndrome (metabolism), Stiff-Person Syndrome (physiopathology), Stiff-Person Syndrome (radionuclide imaging), gamma-Aminobutyric Acid (metabolism), positron emission tomography, stiff person syndrome.
MESH :
- chemical , metabolism : gamma-Aminobutyric Acid.
- metabolism : Stiff-Person Syndrome.
- physiopathology : Stiff-Person Syndrome.
- radionuclide imaging : Stiff-Person Syndrome.
- Female, Humans, Male, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography.

Abstract

We measured expression of central nervous system GABA‐A receptors with 11C‐flumazenil (11C‐FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C‐FMZ binding potential (BP) in motor‐premotor cortex, and increased 11C‐FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA‐A receptors dysfunction in SPS, possibly concurring to the motor symptoms. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/FF5ACEFD92831171FAF99F889FC39B417948023B/fulltext/pdf

DOI: 10.1002/mds.21441

Affiliations:

Le document en format XML

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<term>Middle Aged</term>
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<term>Positron emission tomography</term>
<term>Positron-Emission Tomography</term>
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<term>Stiff-Person Syndrome (physiopathology)</term>
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<front><div type="abstract" xml:lang="en">We measured expression of central nervous system GABA‐A receptors with 11C‐flumazenil (11C‐FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced 11C‐FMZ binding potential (BP) in motor‐premotor cortex, and increased 11C‐FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA‐A receptors dysfunction in SPS, possibly concurring to the motor symptoms. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

PET evidence of central GABAergic changes in stiff‐person syndrome

PET evidence of central GABAergic changes in stiff‐person syndrome

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.